Specificity of receptor tyrosine kinase signaling: transient versus sustained extracellular signal-regulated kinase activation

A quantity of completely different intracellular signing pathways have been proven to be activated by receptor tyrosine kinases. These activation occasions embody the phosphoinositide 3-kinase, 70 kDa S6 kinase, mitogen-activated protein kinase (MAPK), phospholipase C-gamma, and the Jak/STAT pathways. The exact function of every of these pathways in cell signing stays to be resolved, however research on the differentiation of mammalian

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