Glycogen synthase kinase-3beta regulates cyclin D1 proteolysis and subcellular localization

The actions of cyclin D-dependent kinases serve to combine extracellular signing throughout G1 section with the cell-cycle engine that regulates DNA replication and mitosis. Induction of D-type cyclins and their meeting into holoenzyme complexes rely upon mitogen stimulation. Conversely, the truth that D-type cyclins are labile proteins ensures that the subunit pool shrinks quickly when cells are disadvantaged of

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