Extracellular signal-regulated kinases 2 (Erk2) and Erk5 in the central nervous system differentially contribute to central sensitization in male mice

Nervous techniques are designed to turn out to be additional delicate to afferent nociceptive stimuli beneath sure circumstances equivalent to irritation and nerve damage. How ache hypersensitivity comes about is essential subject in the discipline because it in the end outcomes in persistent ache. Central sensitization represents enhanced ache sensitivity due to elevated neural signaling

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