Perfluorooctane sulfonate (PFOS) is amongst the most considerable natural pollution and is broadly distributed in the setting, wildlife, and people. Its poisonous results and organic hazards are related to its lengthy elimination half-life in people. However, the way it impacts renal tubular cells (RTCs) stays unclear.
In this examine, PFOS was noticed to mediate the improve in reactive oxygen species (ROS) technology, adopted by the activation of the extracellular-signal-regulated kinase half of (ERK1/2) pathway, which induced autophagy in RTCs. Although PFOS remedy induced autophagy after 6 h, extended remedy (24 h) diminished the autophagic flux by rising lysosomal membrane permeability (LMP), resulting in elevated p62 protein accumulation and subsequent apoptosis.
The improve in LMP was visualized through elevated inexperienced fluorescence with acridine orange staining, and this was attenuated by 3-methyladenine, an autophagy inhibitor. N-acetyl cysteine and an inhibitor of the mitogen-activated protein kinase kinases (U0126) attenuated autophagy and apoptosis.
Taken collectively, these outcomes point out that ROS activation and ROS-mediated phosphorylated ERK1/2 activation are important to activate autophagy, ensuing in the apoptosis of PFOS-treated RTCs. Our findings present perception into the mechanism of PFOS-mediated renal toxicity.
Cell-extracellular matrix (ECM) detachment is understood to down-regulate ERK signalling, an intracellular pathway that’s central for management of cell behaviour. How cell-ECM detachment is linked to down-regulation of ERK signalling, nonetheless, is incompletely understood. Depletion of PHB2 suppressed cell-ECM adhesion induced ERK activation
We present right here that focal adhesion protein Ras Suppressor 1 (RSU1) performs a vital position in cell-ECM detachment induced down-regulation of ERK signalling. We have recognized prohibitin 2 (PHB2), a element of membrane lipid rafts, as a novel binding protein of RSU1, and mapped a serious RSU1-binding website to PHB2 amino acids 150-206 in the C-terminal area of the PHB/SPFH (stomatin/prohibitin/flotillin/HflKC) area.
The PHB2-binding is mediated by a number of websites situated in the N-terminal leucine-rich repeat (LRR) area of RSU-1. . Furthermore, cell-ECM detachment elevated RSU1 affiliation with membrane lipid rafts and interplay with PHB2. Expression of venus-tagged wild-type RSU1, however not that of venus-tagged PHB2-binding faulty RSU1 mutant in which the N-terminal
Finally, knockout of RSU1 or inhibition of RSU1 interplay with PHB2 by overexpression of the main RSU1-binding PHB2 fragment (amino acids 150-206) successfully suppressed the cell-ECM detachment induced down-regulation of ERK signalling. LRR area is deleted, restored cell-ECM detachment induced down-regulation of ERK signalling. Our outcomes establish a novel RSU1-PHB2 signalling axis that senses cell-ECM detachment and hyperlinks it to down-regulation of ERK signalling.
Renalase, a novel flavoprotein that’s primarily expressed in the kidney and coronary heart, performs a vital position in hypertension. Recent research have proven that renalase is expressed at low ranges in the serum of sufferers with coronary heart failure, whereas the position of renalase and its mechanism in cardiac failure is unclear.
Adult Sprague-Dawley (SD) rats had been used to research the position and operate of renalase in the pathological course of of transverse aortic constriction (TAC)-induced coronary heart failure. Renalase-human protein chip evaluation confirmed that renalase was straight related to P38 and extracellular signal-regulated protein kinase half of (ERK1/2) signaling.
We additional used lentivirus-mediated RNA interference to check the position of renalase in the development of pathological ventricular hypertrophy and discovered that renalase inhibition attenuated the noradrenaline-induced hypertrophic response in vitro or the strain overload-induced hypertrophic response in vivo.
Recombinant renalase protein considerably alleviated strain overload-induced cardiac failure and was related to P38 and ERK1/2 signaling. These findings show that renalase is a possible biomarker of hypertrophy and that exogenous recombinant renalase is a possible and novel drug for coronary heart failure.
Chemotherapy-induced peripheral neuropathy is a standard issue in limiting remedy which might end result in remedy cessation or dose discount. Gabapentin, a calcium channel inhibitor, and duloxetine, a serotonin noradrenaline reuptake inhibitor, are used to deal with a spread of ache circumstances corresponding to continual low again ache, postherpetic neuralgia, and diabetic neuropathy.
It has been reported that administration of gabapentin suppressed oxaliplatin- and paclitaxel-induced mechanical hyperalgesia in rats. Moreover, duloxetine has been proven to suppress oxaliplatin-induced chilly allodynia in rats. However, the mechanisms by which these medication forestall oxaliplatin- and paclitaxel-induced neuropathy stay unknown.
Behavioral assays had been carried out utilizing chilly plate and the von Frey check. The expression ranges of proteins had been examined utilizing western blot evaluation. In this examine, we investigated the mechanisms by which gabapentin and duloxetine forestall oxaliplatin- and paclitaxel-induced neuropathy in mice.
We discovered that gabapentin and duloxetine prevented the growth of oxaliplatin- and paclitaxel-induced chilly and mechanical allodynia. In addition, our outcomes revealed that gabapentin and duloxetine suppressed extracellular signal-regulated protein kinase half of (ERK1/2) phosphorylation in the spinal wire of mice.
 Alpha-bungarotoxin, CF640r |
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| 9-00004 | Biotium |
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Description: Minimum order quantity: 1 unit of 100uG |
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 Alpha-bungarotoxin, CF488a |
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| 9-00005 | Biotium |
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Description: Minimum order quantity: 1 unit of 500uG |
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 Alpha-bungarotoxin CF488a |
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| 9-00005 | Biotium |
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Description: Minimum order quantity: 1 unit of 100uG |
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 Alpha-bungarotoxin, CF568 |
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| 9-00006 | Biotium |
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Description: Minimum order quantity: 1 unit of 500uG |
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Alpha-bungarotoxin, CF568 |
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| 9-00006 | Biotium |
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Description: Minimum order quantity: 1 unit of 100uG |
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 Alpha-bungarotoxin, CF594 |
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| 9-00007 | Biotium |
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Description: Minimum order quantity: 1 unit of 500uG |
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 Alpha-bungarotoxin CF594 |
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| 9-00007 | Biotium |
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Description: Minimum order quantity: 1 unit of 100uG |
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 Alpha-bungarotoxin, CF633 |
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| 9-00009 | Biotium |
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Description: Minimum order quantity: 1 unit of 500uG |
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Alpha-bungarotoxin, CF633 |
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| 9-00009 | Biotium |
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Description: Minimum order quantity: 1 unit of 100uG |
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 Alpha-bungarotoxin |
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| 00010-1 | Biotium | 1MG | EUR 168 |
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Description: Minimum order quantity: 1 unit of 1MG |
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 Fluorescein-Alpha-bungarotoxin |
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| 00011 | Biotium | 500uG | EUR 367 |
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Description: Minimum order quantity: 1 unit of 500uG |
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 Tetramethylrhodamine-Alpha-bungarotoxin |
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| 00012 | Biotium | 500uG | EUR 383 |
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Description: Minimum order quantity: 1 unit of 500uG |
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) Fluorescein-alpha-bungarotoxin: (10x50ug) |
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| 00013 | Biotium | 10ST | EUR 417 |
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Description: Minimum order quantity: 1 unit of 10ST |
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) Tetramethylrhodamine-alpha-bungarotoxin: (10x50ug) |
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| 00014 | Biotium | 10ST | EUR 466 |
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Description: Minimum order quantity: 1 unit of 10ST |
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: (500ug)) Sulforhodamine 101-a-bungarotoxin (Texas Red--a-bungarotoxin): (500ug) |
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| 00015 | Biotium | 500uG | EUR 466 |
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Description: Minimum order quantity: 1 unit of 500uG |
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: (10x50ug)) Sulforhodamine 101-a-bungarotoxin (Texas Red--a-bungarotoxin): (10x50ug) |
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| 00016 | Biotium | 10ST | EUR 523 |
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Description: Minimum order quantity: 1 unit of 10ST |
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 Biotin-xx-a-bungarotoxin |
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| 00017 | Biotium | 500uG | EUR 433 |
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Description: Minimum order quantity: 1 unit of 500uG |
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 Alpha-Bungarotoxin, CF555 conjugate |
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| 9-00018 | Biotium |
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Description: Minimum order quantity: 1 unit of 500uG |
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Alpha-Bungarotoxin, CF555 conjugate |
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| 9-00018 | Biotium |
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Description: Minimum order quantity: 1 unit of 100ug |
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 Biotin-cAMP, diisopropylethylammonium salt: |
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| 00020 | Biotium | 1MG | EUR 314 |
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Description: Minimum order quantity: 1 unit of 1MG |
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) Biotin-cAMP, diisopropylethylammonium salt: (20x50ug) |
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| 00020-1 | Biotium | 20ST | EUR 418 |
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Description: Minimum order quantity: 1 unit of 20ST |
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 Biotin-cGMP, diisopropylethylammonium salt: |
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| 00021 | Biotium | 1MG | EUR 344 |
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Description: Minimum order quantity: 1 unit of 1MG |
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) Biotin-cGMP, diisopropylethylammonium salt: (20x50ug) |
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| 00021-1 | Biotium | 20ST | EUR 448 |
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Description: Minimum order quantity: 1 unit of 20ST |
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 Cyanine 644-cAMP: |
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| 00022 | Biotium | 1MG | EUR 491 |
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Description: Minimum order quantity: 1 unit of 1MG |
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) Cyanine 644-cAMP: (20x50ug) |
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| 00022-1 | Biotium | 20ST | EUR 625 |
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Description: Minimum order quantity: 1 unit of 20ST |
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 Fluorescein Methotrexate, triammonium salt: |
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| 00023 | Biotium | 1MG | EUR 281 |
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Description: Minimum order quantity: 1 unit of 1MG |
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 Staurosporine |
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| 00025 | Biotium | 100uG | EUR 139 |
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Description: Minimum order quantity: 1 unit of 100uG |
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 Alpha-bungarotoxin, CF543 |
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| 00026 | Biotium | 500uG | EUR 494 |
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Description: Minimum order quantity: 1 unit of 500uG |
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 Rhodamine phalloidin 300u |
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| 00027 | Biotium | 300 | EUR 345 |
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Description: Minimum order quantity: 1 unit of 300 |
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 Biotin-xx-phalloidin |
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| 00028 | Biotium | 100U | EUR 428 |
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Description: Minimum order quantity: 1 unit of 100U |
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 Fluorescein-phalloidin |
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| 00030 | Biotium | 300U | EUR 345 |
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Description: Minimum order quantity: 1 unit of 300U |
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 Rhodamine 110 phalloidin |
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| 00032 | Biotium | 300ST | EUR 345 |
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Description: Minimum order quantity: 1 unit of 300ST |
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 Phalloidin) Sulforhodamine 101 (Texas-Red) Phalloidin |
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| 00033 | Biotium | 300EU | EUR 345 |
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Description: Minimum order quantity: 1 unit of 300EU |
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 Phalloidin, CF405M |
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| 00034 | Biotium | 300U | EUR 442 |
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Description: Minimum order quantity: 1 unit of 300U |
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Phalloidin, CF405M |
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| 00034-T | Biotium | 50U | EUR 133 |
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Description: Minimum order quantity: 1 unit of 50U |
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 CF488A-cAMP |
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| 00036 | Biotium | 100ug | EUR 172 |
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Description: Minimum order quantity: 1 unit of 100ug |
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 CF640R-cAMP |
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| 00037 | Biotium | 100ug | EUR 172 |
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Description: Minimum order quantity: 1 unit of 100ug |
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 Phalloidin, CF555 |
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| 00040 | Biotium | 300U | EUR 442 |
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Description: Minimum order quantity: 1 unit of 300U |
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Phalloidin, CF555 |
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| 00040-T | Biotium | 50U | EUR 133 |
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Description: Minimum order quantity: 1 unit of 50U |
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 Phalloidin, CF647 |
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| 00041 | Biotium | 300U | EUR 442 |
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Description: Minimum order quantity: 1 unit of 300U |
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Phalloidin, CF647 |
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| 00041-T | Biotium | 50U | EUR 133 |
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Description: Minimum order quantity: 1 unit of 50U |
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 Phalloidin, CF488A |
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| 00042 | Biotium | 300U | EUR 442 |
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Description: Minimum order quantity: 1 unit of 300U |
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Phalloidin, CF488A |
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| 00042-T | Biotium | 50U | EUR 133 |
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Description: Minimum order quantity: 1 unit of 50U |
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 Phalloidin, CF543 |
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| 00043 | Biotium | 300U | EUR 442 |
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Description: Minimum order quantity: 1 unit of 300U |
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Phalloidin, CF543 |
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| 00043-T | Biotium | 50U | EUR 133 |
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Description: Minimum order quantity: 1 unit of 50U |
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 Phalloidin, CF568 |
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| 00044 | Biotium | 300U | EUR 442 |
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Description: Minimum order quantity: 1 unit of 300U |
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Phalloidin, CF568 |
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| 00044-T | Biotium | 50U | EUR 133 |
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Description: Minimum order quantity: 1 unit of 50U |
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 Phalloidin, CF594 |
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| 00045 | Biotium | 300U | EUR 442 |
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Description: Minimum order quantity: 1 unit of 300U |
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Phalloidin, CF594 |
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| 00045-T | Biotium | 50U | EUR 133 |
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Description: Minimum order quantity: 1 unit of 50U |
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 Phalloidin, CF633 |
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| 00046 | Biotium | 300U | EUR 442 |
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Description: Minimum order quantity: 1 unit of 300U |
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Phalloidin, CF633 |
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| 00046-T | Biotium | 50U | EUR 133 |
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Description: Minimum order quantity: 1 unit of 50U |
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 Phalloidin, CF660R |
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| 00047 | Biotium | 300U | EUR 442 |
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Description: Minimum order quantity: 1 unit of 300U |
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Phalloidin, CF660R |
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| 00047-T | Biotium | 50U | EUR 133 |
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Description: Minimum order quantity: 1 unit of 50U |
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 Phalloidin, CF680R |
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| 00048 | Biotium | 300U | EUR 466 |
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Description: Minimum order quantity: 1 unit of 300U |
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Phalloidin, CF680R |
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| 00048-T | Biotium | 50U | EUR 133 |
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Description: Minimum order quantity: 1 unit of 50U |
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 Phalloidin, CF350 |
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| 00049 | Biotium | 300U | EUR 442 |
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Description: Minimum order quantity: 1 unit of 300U |
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Phalloidin, CF350 |
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| 00049-T | Biotium | 50U | EUR 133 |
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Description: Minimum order quantity: 1 unit of 50U |
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 Phalloidin, CF640R |
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| 00050 | Biotium | 300U | EUR 442 |
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Description: Minimum order quantity: 1 unit of 300U |
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Phalloidin, CF640R |
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| 00050-T | Biotium | 50U | EUR 133 |
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Description: Minimum order quantity: 1 unit of 50U |
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 Phalloidin, CF532 |
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| 00051 | Biotium | 300U | EUR 442 |
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Description: Minimum order quantity: 1 unit of 300U |
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Phalloidin, CF532 |
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| 00051-T | Biotium | 50U | EUR 133 |
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Description: Minimum order quantity: 1 unit of 50U |
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 Phalloidin, CF660C |
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| 00052 | Biotium | 300U | EUR 442 |
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Description: Minimum order quantity: 1 unit of 300U |
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Phalloidin, CF660C |
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| 00052-T | Biotium | 50U | EUR 133 |
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Description: Minimum order quantity: 1 unit of 50U |
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 Phalloidin, CF680 |
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| 00053 | Biotium | 300U | EUR 466 |
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Description: Minimum order quantity: 1 unit of 300U |
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Phalloidin, CF680 |
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| 00053-T | Biotium | 50U | EUR 147 |
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Description: Minimum order quantity: 1 unit of 50U |
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 Phalloidin, CF430 |
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| 00054 | Biotium | 300U | EUR 449 |
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Description: Minimum order quantity: 1 unit of 300U |
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Phalloidin, CF430 |
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| 00054-T | Biotium | 50U | EUR 139 |
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Description: Minimum order quantity: 1 unit of 50U |
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 Phalloidin, CF440 |
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| 00055 | Biotium | 300U | EUR 449 |
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Description: Minimum order quantity: 1 unit of 300U |
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Phalloidin, CF440 |
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| 00055-T | Biotium | 50U | EUR 139 |
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Description: Minimum order quantity: 1 unit of 50U |
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 Cholera Toxin Subunit B, CF488A conjugate |
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| 00070 | Biotium | 100ug | EUR 261 |
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Description: Minimum order quantity: 1 unit of 100ug |
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 Cholera Toxin Subunit B, CF568 conjugate |
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| 00071 | Biotium | 100ug | EUR 261 |
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Description: Minimum order quantity: 1 unit of 100ug |
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 Cholera Toxin Subunit B, CF594 conjugate |
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| 00072 | Biotium | 100ug | EUR 261 |
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Description: Minimum order quantity: 1 unit of 100ug |
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 Cholera Toxin Subunit B, CF640R conjugate |
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| 00073 | Biotium | 100ug | EUR 264 |
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Description: Minimum order quantity: 1 unit of 100ug |
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 Cholera Toxin Subunit B, CF532 conjugate |
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| 00074 | Biotium | 100ug | EUR 264 |
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Description: Minimum order quantity: 1 unit of 100ug |
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 Cholera Toxin Subunit B, CF543 conjugate |
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| 00075 | Biotium | 100ug | EUR 264 |
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Description: Minimum order quantity: 1 unit of 100ug |
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 Cholera Toxin Subunit B, CF620R conjugate |
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| 00076 | Biotium | 100ug | EUR 264 |
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Description: Minimum order quantity: 1 unit of 100ug |
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 Cholera Toxin Subunit B, CF633 conjugate |
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| 00077 | Biotium | 100ug | EUR 264 |
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Description: Minimum order quantity: 1 unit of 100ug |
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 Cholera Toxin Subunit B, CF660R conjugate |
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| 00078 | Biotium | 100ug | EUR 264 |
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Description: Minimum order quantity: 1 unit of 100ug |
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 Cholera Toxin Subunit B, CF680R conjugate |
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| 00079 | Biotium | 100ug | EUR 282 |
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Description: Minimum order quantity: 1 unit of 100ug |
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 Human Transferrin, CF488A conjugate |
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| 00081 | Biotium | 1mg | EUR 149 |
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Description: Minimum order quantity: 1 unit of 1mg |
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 Human Transferrin, CF543 conjugate |
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| 00082 | Biotium | 1mg | EUR 149 |
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Description: Minimum order quantity: 1 unit of 1mg |
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 Human Transferrin, CF568 conjugate |
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| 00083 | Biotium | 1mg | EUR 149 |
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Description: Minimum order quantity: 1 unit of 1mg |
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 Human Transferrin, CF594 conjugate |
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| 00084 | Biotium | 1mg | EUR 149 |
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Description: Minimum order quantity: 1 unit of 1mg |
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 Human Transferrin, CF640R conjugate |
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| 00085 | Biotium | 1mg | EUR 149 |
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Description: Minimum order quantity: 1 unit of 1mg |
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 Human Transferrin, CF680R conjugate |
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| 00086 | Biotium | 1mg | EUR 149 |
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Description: Minimum order quantity: 1 unit of 1mg |
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 Human Transferrin, CF750 conjugate |
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| 00087 | Biotium | 1mg | EUR 155 |
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Description: Minimum order quantity: 1 unit of 1mg |
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 HIV-1 tat recombinant antigen |
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| 00110-V-01mg | Virogen | 0,1 mg | EUR 267.5 |
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Description: HIV-1 tat recombinant antigen full length 15 kDa |
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HIV-1 tat recombinant antigen |
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| 00110-V-1000ug | Virogen | 1000 ug | EUR 1282.5 |
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Description: HIV-1 tat recombinant antigen full length 15 kDa |
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 HIV-1 GAG P24 Recombinant Antigen |
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| 00111-V-01mg | Virogen | 0,1 mg | EUR 267.5 |
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Description: HIV-1 gag p24 recombinant antigen a.a 77 to a.a 436 of the HIV-1 gag region 39 kDa |
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HIV-1 GAG P24 Recombinant Antigen |
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| 00111-V-1000ug | Virogen | 1000 ug | EUR 1282.5 |
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Description: HIV-1 gag p24 recombinant antigen a.a 77 to a.a 436 of the HIV-1 gag region 39 kDa |
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 HIV-1 nef recombinant antigen |
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| 00112-V-01mg | Virogen | 0,1 mg | EUR 267.5 |
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Description: HIV-1 nef recombinant antigen a.a 3 to a.a 190 of the HIV-1 nef region 20 kDa |
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HIV-1 nef recombinant antigen |
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| 00112-V-1000ug | Virogen | 1000 ug | EUR 1282.5 |
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Description: HIV-1 nef recombinant antigen a.a 3 to a.a 190 of the HIV-1 nef region 20 kDa |
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 HIV-1 env gp41 recombinant antigen |
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| 00113-V-01mg | Virogen | 0,1 mg | EUR 267.5 |
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Description: HIV-1 env gp41 recombinant antigen a.a 466 to a.a 753 of the HIV-1 env region 32 kDa |
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HIV-1 env gp41 recombinant antigen |
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| 00113-V-1000ug | Virogen | 1000 ug | EUR 1282.5 |
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Description: HIV-1 env gp41 recombinant antigen a.a 466 to a.a 753 of the HIV-1 env region 32 kDa |
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 HIV-2 GP 36 Recombinant Antigen |
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| 00114-V-01mg | Virogen | 0,1 mg | EUR 267.5 |
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Description: HIV -2 env gp36 recombinant antigen a.a 390 to a.a 702 of the HIV-2 env region 34 kDa |
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HIV-2 GP 36 Recombinant Antigen |
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| 00114-V-1000ug | Virogen | 1000 ug | EUR 1282.5 |
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Description: HIV -2 env gp36 recombinant antigen a.a 390 to a.a 702 of the HIV-2 env region 34 kDa |
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 HCV core recombinant antigen |
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| 00115-V-01mg | Virogen | 0,1 mg | EUR 267.5 |
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Description: HCV core recombinant antigen a.a 2 to a.a 192 of HCV polyprotein 22 kDa |
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HCV core recombinant antigen |
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| 00115-V-1000ug | Virogen | 1000 ug | EUR 1282.5 |
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Description: HCV core recombinant antigen a.a 2 to a.a 192 of HCV polyprotein 22 kDa |
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 HCV core recombinant antigen, Biotin conjugate |
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| 00115-V-B-01mg | Virogen | 0,1 mg | EUR 267.5 |
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Description: HCV core recombinant antigen a.a 2 to a.a 192 of HCV polyprotein 22 kDa. Biotin conjugate. |
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HCV core recombinant antigen, Biotin conjugate |
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| 00115-V-B-1000ug | Virogen | 1000 ug | EUR 1282.5 |
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Description: HCV core recombinant antigen a.a 2 to a.a 192 of HCV polyprotein 22 kDa. Biotin conjugate. |
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 HCV core recombinant antigen, FITC conjugate |
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| 00115-V-F-01mg | Virogen | 0,1 mg | EUR 267.5 |
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Description: HCV core recombinant antigen a.a 2 to a.a 192 of HCV polyprotein 22 kDa. Fluorescein conjugate. |
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HCV core recombinant antigen, FITC conjugate |
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| 00115-V-F-1000ug | Virogen | 1000 ug | EUR 1282.5 |
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Description: HCV core recombinant antigen a.a 2 to a.a 192 of HCV polyprotein 22 kDa. Fluorescein conjugate. |
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 HCV core recombinant antigen, Rhodamine |
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| 00115-V-R-01mg | Virogen | 0,1 mg | EUR 267.5 |
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Description: HCV core recombinant antigen a.a 2 to a.a 192 of HCV polyprotein 22 kDa . Rhodamine conjugate. |
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HCV core recombinant antigen, Rhodamine |
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| 00115-V-R-1000ug | Virogen | 1000 ug | EUR 1282.5 |
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Description: HCV core recombinant antigen a.a 2 to a.a 192 of HCV polyprotein 22 kDa . Rhodamine conjugate. |
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 HCV NS4 recombinant antigen NS4a+b |
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| 00116-V-01mg | Virogen | 0,1 mg | EUR 267.5 |
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Description: HCV NS4 recombinant antigen NS4a+b a.a 1658 to a.a 1863 of HCV polyprotein, 19 kDa. |
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HCV NS4 recombinant antigen NS4a+b |
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| 00116-V-1000ug | Virogen | 1000 ug | EUR 1282.5 |
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Description: HCV NS4 recombinant antigen NS4a+b a.a 1658 to a.a 1863 of HCV polyprotein, 19 kDa. |
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 HCV NS4 recombinant antigen NS4a+b, Biotin |
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| 00116-V-B-01mg | Virogen | 0,1 mg | EUR 267.5 |
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Description: HCV NS4 recombinant antigen NS4a+b a.a 1658 to a.a 1863 of HCV polyprotein, 19 kDa. Biotin conjugate. |
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HCV NS4 recombinant antigen NS4a+b, Biotin |
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| 00116-V-B-1000ug | Virogen | 1000 ug | EUR 1282.5 |
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Description: HCV NS4 recombinant antigen NS4a+b a.a 1658 to a.a 1863 of HCV polyprotein, 19 kDa. Biotin conjugate. |
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 HCV NS4 recombinant antigen NS4a+b, FITC |
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| 00116-V-F-01mg | Virogen | 0,1 mg | EUR 267.5 |
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Description: HCV NS4 recombinant antigen NS4a+b a.a 1658 to a.a 1863 of HCV polyprotein, 19 kDa. Fluorescein conjugate. |
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HCV NS4 recombinant antigen NS4a+b, FITC |
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| 00116-V-F-1000ug | Virogen | 1000 ug | EUR 1282.5 |
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Description: HCV NS4 recombinant antigen NS4a+b a.a 1658 to a.a 1863 of HCV polyprotein, 19 kDa. Fluorescein conjugate. |
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 HCV NS4 recombinant antigen NS4a+b, Rhodamine |
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| 00116-V-R-01mg | Virogen | 0,1 mg | EUR 267.5 |
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Description: HCV NS4 recombinant antigen NS4a+b a.a 1658 to a.a 1863 of HCV polyprotein, 19 kDa. Rhodamine conjugate. |
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HCV NS4 recombinant antigen NS4a+b, Rhodamine |
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| 00116-V-R-1000ug | Virogen | 1000 ug | EUR 1282.5 |
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Description: HCV NS4 recombinant antigen NS4a+b a.a 1658 to a.a 1863 of HCV polyprotein, 19 kDa. Rhodamine conjugate. |
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 HCV NS3 recombinant antigen |
|||
| 00117-V-01mg | Virogen | 0,1 mg | EUR 267.5 |
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Description: HCV NS3 recombinant antigen a.a 1400 to a.a 1643 of HCV polyprotein 22 kDa |
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HCV NS3 recombinant antigen |
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| 00117-V-1000ug | Virogen | 1000 ug | EUR 1282.5 |
|
Description: HCV NS3 recombinant antigen a.a 1400 to a.a 1643 of HCV polyprotein 22 kDa |
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 HBV core recombinant antigen |
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| 00120-V-01mg | Virogen | 0,1 mg | EUR 267.5 |
|
Description: HBV core recombinant antigen HBcAg a.a 1 to a.a 183 of HBV core antigen 18 kDa |
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HBV core recombinant antigen |
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| 00120-V-1000ug | Virogen | 1000 ug | EUR 1282.5 |
|
Description: HBV core recombinant antigen HBcAg a.a 1 to a.a 183 of HBV core antigen 18 kDa |
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 HBV core recombinant antigen, Delta |
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| 00121-V-01mg | Virogen | 0,1 mg | EUR 267.5 |
|
Description: HBV core recombinant antigen HBcAg a.a 1 to a.a 144 of HBV core antigen 16 kDa |
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HBV core recombinant antigen, Delta |
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| 00121-V-1000ug | Virogen | 1000 ug | EUR 1282.5 |
|
Description: HBV core recombinant antigen HBcAg a.a 1 to a.a 144 of HBV core antigen 16 kDa |
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 HBV surface recombinant antigen HBsAg |
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| 00122-V-01mg | Virogen | 0,1 mg | EUR 267.5 |
|
Description: HBV surface recombinant antigen HBsAg antigen 22 kDa Pichia pastoris recombinant |
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HBV surface recombinant antigen HBsAg |
|||
| 00122-V-1000ug | Virogen | 1000 ug | EUR 1282.5 |
|
Description: HBV surface recombinant antigen HBsAg antigen 22 kDa Pichia pastoris recombinant |
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 HBV surface recombinant antigen HBsAg antigen |
|||
| 00123-V-01mg | Virogen | 0,1 mg | EUR 267.5 |
|
Description: HBV surface recombinant antigen HBsAg antigen 22 kDa Pichia pastoris recombinant High purity |
|||
HBV surface recombinant antigen HBsAg antigen |
|||
| 00123-V-1000ug | Virogen | 1000 ug | EUR 1282.5 |
|
Description: HBV surface recombinant antigen HBsAg antigen 22 kDa Pichia pastoris recombinant High purity |
|||
HBV surface recombinant antigen HBsAg antigen |
|||
| 00124-V-01mg | Virogen | 0,1 mg | EUR 267.5 |
|
Description: HBV surface recombinant antigen HBsAg antigen 31 kDa E. coli recombinant |
|||
HBV surface recombinant antigen HBsAg antigen |
|||
| 00124-V-1000ug | Virogen | 1000 ug | EUR 1282.5 |
|
Description: HBV surface recombinant antigen HBsAg antigen 31 kDa E. coli recombinant |
|||
 ORF2 recombinant antigen) HEV (Birma) ORF2 recombinant antigen |
|||
| 00131-V-01mg | Virogen | 0,1 mg | EUR 267.5 |
|
Description: HEV (Birma) ORF2 recombinant antigen a.a. 633 to a.a 659. |
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HEV (Birma) ORF2 recombinant antigen |
|||
| 00131-V-1000ug | Virogen | 1000 ug | EUR 1282.5 |
|
Description: HEV (Birma) ORF2 recombinant antigen a.a. 633 to a.a 659. |
|||
HEV (Birma) ORF2 recombinant antigen |
|||
| 00132-V-01mg | Virogen | 0,1 mg | EUR 267.5 |
|
Description: HEV (Birma) ORF2 recombinant antigen a.a. 403 to a.a 461. |
|||
HEV (Birma) ORF2 recombinant antigen |
|||
| 00132-V-1000ug | Virogen | 1000 ug | EUR 1282.5 |
|
Description: HEV (Birma) ORF2 recombinant antigen a.a. 403 to a.a 461. |
|||
 AA 403-461 HEV Birma ORF2 Recombinant Antigen |
|||
| 00133-V-01mg | Virogen | 0,1 mg | EUR 267.5 |
|
Description: HEV (Birma) ORF2 recombinant antigen a.a. 92 to a.a 123. |
|||
AA 403-461 HEV Birma ORF2 Recombinant Antigen |
|||
| 00133-V-1000ug | Virogen | 1000 ug | EUR 1282.5 |
|
Description: HEV (Birma) ORF2 recombinant antigen a.a. 92 to a.a 123. |
|||
 T, Pallidum recombinant antigen p15 |
|||
| 00141-V-01mg | Virogen | 0,1 mg | EUR 267.5 |
|
Description: T. Pallidum recombinant antigen p15 (full length) |
|||
T, Pallidum recombinant antigen p15 |
|||
| 00141-V-1000ug | Virogen | 1000 ug | EUR 1282.5 |
|
Description: T. Pallidum recombinant antigen p15 (full length) |
|||
 T, Pallidum recombinant antigen p17 |
|||
| 00142-V-01mg | Virogen | 0,1 mg | EUR 267.5 |
|
Description: T. Pallidum recombinant antigen p17 (full length) |
|||
T, Pallidum recombinant antigen p17 |
|||
| 00142-V-1000ug | Virogen | 1000 ug | EUR 1282.5 |
|
Description: T. Pallidum recombinant antigen p17 (full length) |
|||
 T, Pallidum recombinant antigen p45 |
|||
| 00143-V-01mg | Virogen | 0,1 mg | EUR 267.5 |
|
Description: T. Pallidum recombinant antigen p45 (full length) |
|||
T, Pallidum recombinant antigen p45 |
|||
| 00143-V-1000ug | Virogen | 1000 ug | EUR 1282.5 |
|
Description: T. Pallidum recombinant antigen p45 (full length) |
|||
 T, pallidum recombinant antigen TmpA |
|||
| 00144-V-01mg | Virogen | 0,1 mg | EUR 267.5 |
|
Description: T. Pallidum recombinant antigen TmpA (full length) |
|||
T, pallidum recombinant antigen TmpA |
|||
| 00144-V-1000ug | Virogen | 1000 ug | EUR 1282.5 |
|
Description: T. Pallidum recombinant antigen TmpA (full length) |
|||
 HCV core 2-119aa recombinant antigen |
|||
| 00150-V-01mg | Virogen | 0,1 mg | EUR 267.5 |
|
Description: HCV core 2-119aa recombinant antigen. Genotypes available: 1a, 1b, 2a, 2b, 3a, 3b, 3/10, 4, 5, 6a |
|||
HCV core 2-119aa recombinant antigen |
|||
| 00150-V-1000ug | Virogen | 1000 ug | EUR 1282.5 |
|
Description: HCV core 2-119aa recombinant antigen. Genotypes available: 1a, 1b, 2a, 2b, 3a, 3b, 3/10, 4, 5, 6a |
|||
 HCV Core 24 Antigen |
|||
| 00151-V-01mg | Virogen | 0,1 mg | EUR 267.5 |
|
Description: HCV core 24 antigen. |
|||
HCV Core 24 Antigen |
|||
| 00151-V-1000ug | Virogen | 1000 ug | EUR 1282.5 |
|
Description: HCV core 24 antigen. |
|||
Moreover, PD0325901 prevented the growth of oxaliplatin- and paclitaxel-induced neuropathic-like ache conduct by inhibiting ERK1/2 activation in the spinal wire of mice. In abstract, our findings counsel that gabapentin, duloxetine, and PD0325901 forestall the growth of oxaliplatin- and paclitaxel-induced neuropathic-like ache conduct by inhibiting ERK1/2 phosphorylation in mice. Therefore, inhibiting ERK1/2 phosphorylation might be an efficient preventive technique towards oxaliplatin- and paclitaxel-induced neuropathy.
